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KMID : 0358420140570060478
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Korean Journal of Obstetrics and Gynecology
2014 Volume.57 No. 6 p.478 ~ p.483
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The feasibility and efficacy of gonadotropin-releasing hormone agonists for prevention of chemotherapy induced ovarian failure in patient with gynecological malignancies
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Park Chan-Yong
Jung Sun-Young
Lee Kwang-Beom
Yang Sun-Hye
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Abstract
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Objective: To assess the effects of a gonadotropin-releasing hormone agonist (GnRH-a) depot (Leuprolide acetate) in women with gynecologic cancer receiving chemotherapy while taking a continuous add-back on the prevention of premature ovarian failure.
Methods: Fourteen premenopausal patients with gynecological malignancies who had undergone conservation of ovaries surgery received a GnRH-a depot plus add-back until chemotherapy was completed. Four weeks thereafter, a hormonal profile (follicle stimulating hormone) was measured.
Results: The mean follicle stimulating hormone level was 15.8 IU/L. All patients exhibited a restoration of ovarian failure during follow-up. One patient became pregnant during the follow-up period.
Conclusion: In the short term, GnRH-a appears to protect ovarian function and ability to achieve pregnancy following chemotherapy. The result of our study needs further elucidation in a large randomized controlled trial.
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KEYWORD
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Adjuvant chemotherapy, Fertility preservation, Gonadotropin releasing hormone agonist, Ovarian neoplasms, Uterine cervical neoplasms
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